Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?

Amniotic Fluid Stem Cells

p53 and cancer stem cells

The role of p53 in the biology of mammary epithelial stem cells (SC) is well established. p53 may counteract SC expansion by several mechanisms, including restriction of self-renewing divisions and block of reprogramming of somatic/ progenitor cells into SCs. p53 regulates the polarity of cell division in mammary SCs. p53 is often inactivated by loss or mutation in breast cancer. This inactivat...

Amniotic fluid and placental stem cells.

Human amniotic fluid has been used in prenatal diagnosis for more than 70 years. It has proven to be a safe, reliable, and simple screening tool for a wide variety of developmental and genetic diseases. However, there is now evidence that amniotic fluid may have more use than only as a diagnostic tool and may be the source of a powerful therapy for a multitude of congenital and adult disorders....

Human Amniotic Fluid-Derived and Amniotic Membrane-Derived Stem Cells

© Shanghai Jiao Tong University Press, Shanghai and Springer Science+Business Media Dordrecht 2015 R.C. Zhao (ed.), Stem Cells: Basics and Clinical Translation, Translational Medicine Research 1, DOI 10.1007/978-94-017-7273-0_2 Abstract Application of amnion membrane with multiple bioactive biomaterial has over 100 years of history. Amnion membraneand amniotic fluid-derived stem cells mainly in...

Amniotic Fluid and Amniotic Membrane Stem Cells: Marker Discovery

Amniotic fluid (AF) and amniotic membrane (AM) have been recently characterized as promising sources of stem or progenitor cells. Both not only contain subpopulations with stem cell characteristics resembling to adult stem cells, such as mesenchymal stem cells, but also exhibit some embryonic stem cell properties like (i) expression of pluripotency markers, (ii) high expansion in vitro, or (iii...